| 초록 |
Peptide scaffolds can self-assemble into various nanoarchitectures, such as micelles, cylinders, tubes, and vesicles, in aqueous solution. Among them, one-dimensional fibers can form the physical hydrogel via entanglement of fibers using non-covalent interactions. Indeed, supramolecular peptide hydrogels have been largely explored in biomaterials due to their remarkable bioactive, biocompatible and stimuli-responsive features. However, these hydrogels have low mechanical properties and are inclined to breakage under mild disturbance. This fragility considerably limits the practical application of such hydrogels. Here, we engrafted the photoinduced chemical cross-linking method to supramolecular peptide hydrogel for the enhancement of mechanical strength. The peptide sequence is rationally designed and contained small tyrosine moiety which can be crosslinked for the mechanical stability of peptide hydrogel. |
