| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Direct coating method of decellularized extracellular matrix on polymeric scaffold enhanced with magnesium hydroxide for renal tissue regeneration |
| 초록 |
Renal diseases have been recognized as major health issues. In recent years, extracellular matrix (ECM) has been rapidly investigated and applied to the field of tissue engineering and regenerative medicine. In this study, fibroblast-derived extracellular matrix (FDM) was directly coated on three-dimensional porous poly(lactide-co-glycolide) (PLGA) scaffold incorporated with magnesium hydroxide (MH) nanoparticles. Optimized decellularization of confluent cells and MH effect resulted in the formation of a well-adhered and more preserved matrix. The FDM layer was successfully produced on each scaffold surface with reasonable decellularization rate higher than 97%. The improved biocompatibility of PLGA/MH/FDM scaffolds were confirmed by in vitro cell and in vivo animal studies. These results suggest that surface coating of FDM layer supported by MH would be effective for renal tissue regeneration. |
| 저자 |
김윤아1, 전소영2, 유승권3, 권태균2, 정윤기1
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| 소속 |
1한국과학기술(연), 2경북대, 3고려대 |
| 키워드 |
Renal tissue regeneration; Polymeric scaffold; Fibroblast extracellular matrix; Magnesium hydroxide
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| E-Mail |
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