| 초록 |
As an alternative to conventional photodynamic therapy, a sonodynamic therapy (SDT) has been noted for treating deeply adherent tumors without loss of ultrasound energy. However, geometric uncertainties in the process of SDT leads to complications in normal tissues and limits treatment efficiency. Here, we developed perfluorohexane-loaded mesoporous silica-titania nanoparticles (PFH@MSTNs) that enables the induction of cancer cell death by marking the location through tumor specific imaging and generating reactive oxygen species (ROS) by ultrasound. The mesoporous silica nanoparticles were coated with sonosensizter titania on their surface and loaded with PFH as a molecular imaging agent in their pores. We have thoroughly studied the physicochemical properties of nanoparticles, the ability to generate ROS, and providing visual information to the target site. Overall, we anticipate that PFH@MSTNs hold great potential as nanotheranositcs for imaging-guided sonodynamic therapy of cancer. |
