| 초록 |
In the fields of biomaterial fabrication, calcium phosphate coating has been known to be one of the most effective way to accelerate bone formation. However, it will be very hard to prepare the synthetic calcium phosphate similar to the natural bone structure. This is because the in vivo calcification is somewhat different from the way to prepare the artificial calcium phosphate. A variety of biomolecules and osteoblast will be contributing to the evolution of the natural bone. Albumin which is one of the most abundant serum proteins is expected to play a significant role in bone formation. In the investigation, we studied the role of albumin in the formation of calcium phosphate thin films on silica surfaces. The calcium phosphate thin films formed under the influence of albumin. Morphological and chemical characteristics of calcium phosphate films were analyzed using SEM and FTIR. The osteoconductivity of the films were tested by culturing osteoblast on the films. According to the results, we observed highly porous films, somewhat similar to the structure of trabecular bone. FT-IR analysis confirmed the film consists of calcium phosphate. We believe that our observations will be of great use to develop biomimetic bone substitutes in the near future. |
