| 초록 |
There have been many investigations to develop various strategies for the control of cellular behaviors by modifying the topology of biomaterials. In this work, we studied the topographic effect of zinc oxide(ZnO) nanoflower(NF) structure on the growth of MC3T3-E1 osteoblast(OB) cells and their adhesion to the ZnO surface. ZnO NF was prepared on glass substrates by CSD method. According to in vitro culture tests with MC3T3-E1 OB cells, ZnO NF resulted in enhanced DNA content and AP activity compared to the controls of silicone and ZnO substrates. Furthermore, we could confirm the improved adhesion strength of the cells to ZnO NF from the centrifugation tests to measure the adhesion force between them. All these results showed that NF structure of metal oxide might improve the OB adhesion strength to the surface and enhance the cell adhesion and proliferation. This approach can be successfully exploited to improve the OB cell adhesion to the dental implant system using titanium oxide. |
