| 초록 |
Among 2D materials, molybdenum disulfide (MoS2) exhibits photoluminescence in the visible and high absorption at near infrared range. Despite these roperties, the efforts to use MoS2 for bioapplications have been hampered by their instability. Here, we report MoS2 conjugated with hyaluronate (HA) for cancer theranosis. HA facilitates the delivery of MoS2 to tumor cells through HA-receptor mediated endocytosis. In mice inoculated with cancer cells, accumulation of MoS2 in the tumor is observed. The disulfide bonding between MoS2 and thiolated HA tends to degrade in the cytoplasm, releasing MoS2 in stack and enhancing luminescence efficiency. The HA-MoS2 conjugates are readily detected via photoacoustic imaging as well as up/downconversion fluorescence. With NIR illumination, HA-MoS2 enabled effective photothermal tumor ablation. Our results demonstrate the promising potential of HA-MoS2 nanoparticles for cancer theranosis. |
