| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.229 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparations of Porous 3-D Scaffolds from Silk Fibroin |
| 초록 |
Three fabrication techniques; freeze-drying, salt leaching and gas foaming, were used to form porous three-dimensional silk biomaterial matrices. Matrices were characterized for morphological and functional properties related to processing method and conditions. The porosity of the salt leached scaffolds varied between 84-98% with a compressive strength up to 175±3 kPa and the gas foamed scaffolds had porosities of 87-97% and compressive strength up to 280±4 kPa. The freeze-dried scaffolds were prepared at different freezing temperatures (-80 and -20°C), and subsequently treated with different concentrations (15 and 25%) and alcohols. The porosity of these scaffolds was up to 99% and the maximum compressive strength was 30±2 kPa. Changes in silk fibroin structure during processing to form the 3D matrices was determined by FT-IR and XRD. The salt leached and gas foaming techniques produced scaffolds with a useful combination of high compressive strength, interconnected pores and pore sizes greater than 100 microns in diameter. The results suggest that silk-based 3D matrices can be formed for utility in biomaterial applications. |
| 저자 |
진형준1, R. Nazarov2, D. L. Kaplan3
|
| 소속 |
1인하대, 2Department of Chemical & Biological Engineering, 3Tufts Univ. |
| 키워드 |
3D-scaffolds; Silk fibroin; Fibroin Structure; Tissue engineering
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| E-Mail |
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