| 초록 |
Propionibacterium acnes(P. acnes) is the leading cause of acne production. Acne treatment is mainly based on antibiotics(AB), but as drug-resistant strains become widespread. It need to alternative ways have to be developed to higher its eradication rate. Photodynamic therapy(PDT), a promising way for bacterial treatment. Photosensitizer(PS) generates reactive oxygen species(ROS) when irradiated the light. However, ROS have no specificity, can kill not only bacteria, but also normal cells. So, selective photodynamic therapy of target bacteria is an essential strategy for safety. In this study, lipase-responsible lipid nanoparticles loaded with PS and AB(LRLNP) was developed for P.acnes therapeutic agents. LRLNP, consisting of polysaccharides containing ester bonds, loses its stability and releasing AB and PS only in enzymatic environments. As a result, the simultaneous action of AB and PS demonstrated excellent therapeutic effects in vitro and in vivo when compared to AB and PS alone. |
