| 초록 |
Microneedles (MNs) have been extensively exploited as a painless method for transdermal drug delivery and diagnostic point-of-care testing. In part 1 of my talk, I will present a biodegradable, swellable MN enabling shear-induced embedding inside skin following a distal swelling of MN tips by absorbing body fluids. The swellable MNs of 80~90% were embedded into the skin with a superior barrier function by tight sealing of punctured holes. For potential applications, the embeddable MNs were investigated for promoting hair growth. In part 2, I will introduce a sensitive detection platform using nanoporous MNs providing a rapid capture of biomarkers present at sub-nanogram level. The uniform nanopore arrays on the MN surface was prepared by a controlled anodization process and then the nanoporous MNs were functionalized by the immobilization of biomarker-specific antibody to detect estrogen, known as a biomarker of preeclampsia, based on an immunoassay method. |
