| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Functionalized magnetic PLGA Nanospheres for Targeting and Bioimaging of breast cancer |
| 초록 |
Superparamagnetic iron oxide nanoparticles (SPIONs) are actively used as highly sensitive imaging probes to provide contrast in MRI. In this study, we propose the use of SPIONs encapsulated with antibody-conjugated poly(lactic-co-glycolic acid) (PLGA) as a potent theragnostic agent. SPIONs were synthesized by a chemical co-precipitation method of ferric and ferrous ions, and subsequently encapsulated with PLGA by using an emulsification-diffusion method. Herceptin was chemically conjugated to the SPION-encapsulating PLGA nanoparticles to target to human epidermal growth factor receptor 2 (Her2/neu) overexpressing breast cancers. FACS and MR molecular imaging revealed that the Her2/neu overexpressing cell line showed a stronger contrast enhancement than the Her2/neu non-expressing cell lines, and signal intensity of in vivo MR imaging decreased as the concentration of Herceptin increases. |
| 저자 |
이승준1, 김희진2, 김진철3, 정재현2, 김종득1
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| 소속 |
1KAIST, 2숭실대, 3강원대 |
| 키워드 |
PLGA; Magnetic Resonance Imaging; SPIONs; Herceptin
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| E-Mail |
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