| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 가을 (11/02 ~ 11/04, 경원대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Sythesis and Application of Carboxymethyl Chitosan-g- Poly(Ethylene imine) for Gene Carrier |
| 초록 |
Carboxymethyl chitosan(CMCh) was prepared by chemical reaction with mono-chloroacetic acid to low molecular weight water soluble chitosan(LMWSC) of C6-OH (O-Carboxymethyl chitosan) group to apply as gene and drug carrier. For successful gene therapy is safe and effective gene delivery system development is needed. Chitosan to form complexes with DNA degradation by DNase, these complexes has been reported that there is an effect. They have a high positive charge that the PEI with the DNA complex formation is easy. The physicochemical characterisitc of CMCh-PEI2K was investigated by FT-IR, 1H-NMR. Particle size distribution and zeta potential of the CMCh-PEI2K was determined using dynamic light scattering technique. Gel electrophoresis of the CMCh-PEI2K was confirmed that complex the DNA. |
| 저자 |
김영민, 이경재, 김준호, 남정표, 박준규, 김원석, 최창용, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
O-carboxymethyl chitosan; Poly(ethylene imine); DNA.
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| E-Mail |
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