| 초록 |
Polymeric hydrogels have been widely utilized as therapeutic implants or vehicles for tissue engineering and regenerative medicine. The emerging trend in developing hydrogel materials is to create bioactive matrices that can activate the endogenous healing capacity, defined as in situ tissue regeneration, by various physicochemical factors. Many types of hydrogels have been developed; however, it still challenges developing advanced bioactive hydrogels to facilitate in situ tissue regeneration. Herein, we present functional hydrogels releasing either molecular oxygen or metal ions from the matrices. We found that our bioactive hydrogels enhanced endogenous healing processes in vivo, such as tissue infiltration, proliferation, immune regulation, neovascularization, and matrix remodeling. Taken together, we suggest our bioactive hydrogels are promising scaffolds for wound healing and in situ tissue regeneration. |
