| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.665 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Surface modification of magnetites and their applications to molecular imaging |
| 초록 | Receptor targets are especially suitable for such a strategy because small particles, colloidally stable, biocompatible, nontoxic for the body, and biodegradable.1 Iron oxide nanoparticles are routinely used as a contrast agent for magnetic resonance imaging. Polymer coatings are directly involved in their biocompatibility and avoid magnetic aggregation. Surface-modified receptors enhance intracellular uptake and ability to target tumer cells. Folate receptor is a glycosylphosphatidylinositol-anchored, high-affinity in various types of human tumors where it functions by capturing folate to feed tumor cells . In this study iron oxide nanoparticles were coateded with dextran by coprecipitation method. Dextran coated nanoparticles (DNPs) were successfully synthesized, dialysized and characterized using TEM(Fig.1).2 To induce folate and fluorescene isothiocyanate (FITC) to the DNPs, we prepared amine-terminated dextran by oxidizing with sodium periodate and dialyzing in a sodium bicarbonate buffer (pH 8~9) and their size were examined using DLS (Fig.2). Immobilization of folic acid and FITC on the surfaces of magnetite nanoparticles is in progress. Internalization of the nanoparticles into KB cells and their visualization with fluorescence microscope also in progress. (fig.1) TEM of DNPs (fig.2) DLS of amine-terminated DNPs Reference 1. David Portet. Colloid and Interface Science, Volume 238, Issue 1, 1 June 2001, Pages 37-42 2. Heath Pardoe. Magnetism and Magnetic Materials, Volume 225, Issues 1-2, 2001, Pages 41-46 |
| 저자 | 이주희, 강인규 |
| 소속 | 경북대 |
| 키워드 | nanoparticles; magnetite; MR imaging |
