| 초록 |
The importance of biodegradable, pH-responsive polymers and hydrogel materials is being increasingly recognized and extensively studied. Poly(aspartic acid), PASP, and the derivatives are water-soluble, synthetic poly(amino acid)s with protein-like backbone structure, and have been interestingly explored for various industrial and biomedical applications due to their biocompatible and biodegradable nature with pH-sensitive property. In this work, several amino-acid conjugated PASPs and their amphiphilic analogs were prepared by using aminolysis reaction onto polysuccinimide with amino acid methyl ester (including GABA and ß-alanine) and the following hydrolysis process. In addition, PASP-amino acid derivatives were chemically crosslinked to obtain the corresponding gels. These hydrogels were investigated for their swelling behavior with its dependency on pH and salt concentration of medium, hydrolytic degradation and gel matrix morphology. |
