| 초록 |
In tissue engineering, cell adhesion on biomaterial substrates is an essential process since the formation of robust cell adhesive structure on the substrate generally regulates critical cellular activities including proliferation and differentiation. Tetronic-tyramine (Tet-TA) is a synthetic polymer that is capable of undergoing in situ polymerization in the presence of H2O2 and HRP enzyme resulting in a crosslinked hydrogel. This reaction utilizes phenol moieties in Tet-TA, which enables it to incorporate additional bioactive molecules, particularly polypeptides containing tyrosine into the hydrogel, during the polymerization. In this study, we used a RGD containing peptide with a tyrosine end-group to prepare bio-functional Tet-TA hydrogels for the control of cell adhesion and differentiation. The objective of the present study was to investigate the effect of the concentration of the incorporated-peptide on the adhesion, proliferation, and differentiation of myoblasts. |
