| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Rutin-conjugated chitosan-based hydrogels as an injectable biomaterial for wound healing |
| 초록 |
Rutin is flavonol glycoside having a wide spectrum of biological activities such as antioxidative and cytoprotective effects and healing of wounds, which has significant ability in enhancing fibroblast proliferation and collagen production. Herein, we introduce a bioactive and injectable hydrogel based on rutin-conjugated chitosan derivatives. Rutin plays a role as a bioactive molecule supporting fibroblast proliferation and collagen production in a injury site. The synthesized polymers were characterized by 1H NMR, UV-Vis and FT-IR. The amount of released rutin from the hydrogel could be controlled by catalytic concentration The degradation of hydrogels was maintained over one month. Extracts from rutin-conjugated hydrogel enhance significantly the fibroblast proliferation. In vivo study showed that rutin-conjugated hydrogel exhibits a high contraction and granulation formation. Our rutin-conjugated injectable hydrogel may be promising materials for wound healing. |
| 저자 |
윙, 정윤기, 이유진, 박기동
|
| 소속 |
아주대 |
| 키워드 |
Chitosan; Wound healing; Rutin
|
| E-Mail |
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