| 초록 |
Tissue engineering requires the use of polymeric scaffolds that mimic many roles of extracellular matrices (ECM) in the body. Controlling cell-scaffold interactions, such as specific ligand-receptor interactions, physical properties of the scaffolds, and the release of soluble factors from the scaffolds is critical for regulating cell phenotype in tissue engineering. In particular, the control of specific interactions between cell receptors and adhesion ligands is a critical aspect of tissue engineering approaches, including the regulation of many essential features of cellular adhesion, migration, proliferation, and differentiation. Many interaction sites are available in ECM components, and various adhesion peptides have been discovered via competitive adhesion assay and mutagenesis experiments. In this presentation, design parameters of several cell-interactive polymers, potentially useful in tissue engineering applications, will be discussed. |
