| 초록 |
We have developed a microfluidic platform consisting of cylindrical channel structure and a number of individually operatable inlets whose flow could be controlled by computer-controlled pneumatic valve system. Using this platform, we fabricated alginate microfibres coded serially and parallelly with varying chemical composition and topography. We explored the potential use of these fibers as scaffold tissue engineering and drug delivery applications. We cultured primary neuron cells for the regeneration of nervous system by aligning of neurons along the grooved fibers. We developed flat and grooved fibers for the aligned cell-culture. With this fiber, we have aligned neuron and skeletal muscle cells from rat for the regeneration of nervous system and muscles. By the chemical interaction, we have downsized the size of fiber to nano-scale. We have successfully spun microfibers with diverse materials including PLCL and silk protein, and details for these fibers will be introduced. |
