| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
Changing the properties of catechin with polymer by cooling crystallization |
| 초록 |
Engineering the properties of pharmaceutical ingredients by crystallization has been an important subject of research and development. Adding a small amount of polymer as an additive during crystallization could tailor the various properties which could bring lots of advantages. Using this method, we investigated the changed morphology and properties of crystal particles. The particle sizes of catechin were evidently reduced with using hydroxypropyl methylcellulose, polyethyleneimine branched (PEI) and polyvinyl alcohol (PVA). The crystal melting point of catechin with PEI was not observed and the melting point of catechin with PVA was deceased by about 12 ℃ comparing to the pure catechin. Also catechin with PEI showed a sustained release behavior. Those results are predicted to be connected with other thermodynamic properties, offering a chance of stability or release control. Crystallization with polymers is a very simple method and it can be used for tailoring in various areas. |
| 저자 |
김형주, 최규형, 이종휘
|
| 소속 |
중앙대 |
| 키워드 |
polyphenol; catechin; crystallization; polymer
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| E-Mail |
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