| 초록 |
There have been lots of interests modulating immune system to cure or prevent various disease. As a new class of vaccine, mRNA have great advantages in terms of safety, easy storability, and ability to induce broad immune response. The immune response is stimulated by delivering mRNA encoding target antigen into the APCs (e.g. dendritic cells (DCs), macrophages). Depending on the target antigens, mRNA vaccine system can be utilized either as a prophylactic or therapeutic vaccine for pandemic or cancer, respectively. To deliver mRNA effectively to the APCs, specific delivery system is needed. Among various delivery system, microneedles have great potential because of their painless and easy-to-apply system reaching dermis area having abundance of APCs especially DCs. In this study, we developed mRNA releasing microneedles for efficient vaccine delivery. The mRNA lipid nanoparticles were embedded into the HA (Hyaluronic Acid) microneedles for vaccine delivery. |
