| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Specific glycan targeting bifunctional nanoparticles for the capture of exosomes derived from pancreatic cancer patients |
| 초록 |
The mortality rate for pancreatic cancer is high due to lack of powerful early diagnosis technologies. Main obstacles for improving clinical trial result are a diagnosis at an early stage and limited therapeutic efficacy. To overcoming this problem, recently tumor-derived exosomes are attracting interest in cancer diagnosis and treatment field. Here we demonstrate recent technologies highlighting the cancer exosome detection and isolation simultaneously by introducing lectin and Janus nanoparticles. Lectins are glycoproteins that exhibit specific binding affinity for the saccharide moiety of glycoproteins. Cancer cells are known to express or secrete glycoproteins with specific saccharide chain like sialic acid in pancreatic cancer. Therefore, in this study, lectin proteins binding to glycans on the surface of pancreatic cancer cells were screened to develop exosome capturing technology based on lectin-sugar binding capacity instead of antibodies. |
| 저자 |
최용현, 최종훈
|
| 소속 |
중앙대 |
| 키워드 |
Exosome; pancreatic cacner; lectin; glycan; Janus nanoparticle
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| E-Mail |
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