| 학회 |
한국재료학회 |
| 학술대회 |
2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 |
22권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Evaluation of thermosensitive Tempo-oxidized nanocellulose fiber/chitosan hydrogel as an injectable adhesion barrier post-abdominal surgery |
| 초록 |
Tempo–oxidized nanocellulose fiber (OCNF) is a natural material with many promising properties (biocompatibility, hemocompatibility etc.). In this study, we integrated OCNF at varying concentrations with chitosan and created a thermosensitive injectable hydrogel designed as a post-operative anti-adhesion material. The hydrogels underwent sol-gel transition at body temperature as a result of the interaction between chitosan and glycerolphosphate. The samples were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, MTT cell cytotoxicity, and in vivo study in rats. Results showed that the addition of OCNF increased biocompatibility of the hydrogels. Bone marrow-derived mesenchymal stem cells preferred to migrate and adhere at lower OCNF concentrations. A more porous structure was also observed with hydrogels containing OCNF, based on the subcutaneous implanted samples. Application as adhesion barrier after creation of abdominal abrasion in rats showed that the anti-adhesive property is dependent on the concentration of OCNF used. Hematoxylin and Eosin (H&E) staining and analysis also revealed that the addition of OCNF improved biocompatibillity with minimal inflammatory response observed. |
| 저자 |
Trang - Nguyen Ho Minh1, Celine Abueva2, Hai – Ho Van3, Sun – Young Lee1, Byong - Taek Lee2
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| 소속 |
1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
<P>nanocellulose; chitosan; anti-adhesion; injectable hydrogel; tissue engineering</P>
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| E-Mail |
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