| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Signal Transduction of Hyaluronic Acid - Peptide Conjugate for Formyl Peptide Receptor Like 1 Receptor |
| 초록 |
A novel protocol for the synthesis of hyaluronic acid (HA) - peptide (CWRYMVm) conjugate for FPRL1 receptor was successfully developed for its application in vivo. Aminoethyl methacrylated HA (HA-AEMA) was conjugated with CWRYMVm in water via Michael addition reaction between methacrylate group of HA-AEMA and thiol group in cysteine. In vitro signal transduction activity of HA-peptide conjugate for FPRL1 receptor was confirmed from the elevated levels of pERK and calcium ion in RBL-2H3 cells. The partially decreased biological activity of HA-peptide conjugates by the steric hindrance of HA was recovered after its degradation by hyaluronidase treatment. In vivo study of HA-peptide conjugate for FPRL1 receptor in murine model of sepsis showed the improved survival rate of mice. |
| 저자 |
오은주, 한세광
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| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; Formyl peptide receptor like - 1; Conjugation; Michael addition; Signal Transduction
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| E-Mail |
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