| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 20권 2호 |
| 발표분야 | 신진과학자포럼 |
| 제목 | Development of Microbial Cell Factories by Systems and Synthetic Biology Approaches |
| 초록 | In this talk, I will describe recent efforts on systems biology approaches such as genome-scale experimental methods to decipher complex transcriptional regulatory networks in response to various environmental stresses in E. coli. Also, recent achievements on developing synthetic biology tools such as predictive rational/combinatorial design methods of mRNA translation initiation region to control translation efficiency in E. coli and a universal high-throughput screening method using synthetic RNA devices to expedite evolution of inconspicuous metabolite-producing microbes will be introduced. Furthermore, their applications to designing and optimizing synthetic cell factories will be described. References) SW Seo et al. Nat. Commun., 2014, 5, 4910. / SW Seo et al. Nat. Commun., 2015, 6, 7970. / SW Seo et al. Cell Rep. 2015, 12, 1289. / J Yang and SW Seo et al. Nat. Commun. 2013, 4, 1413. / SW Seo et al. Metab. Eng. 2013, 15, 67. / SW Seo et al. Sci. Rep. 2014, 4, 4515. |
| 저자 | 서상우 |
| 소속 | 서울대 |
| 키워드 | Synthetic Biology; Systems Biology; Metabolic Engineering; Biorefinery; Cell Factories |
