| 초록 |
This study presents an exogenous GF delivery platform developed using coacervates (Coa), a tertiary complex of poly(ethylene argininyl aspartate diglyceride) polycation, heparin, and cargo GFs (TGF-β3 and IL-10). Coa encompasses the advantage of high biocompatibility, facile preparation, protection of cargo GFs, and sustained GF release. Coacervate-mediated dual delivery of TGF-β3/IL-10 would exhibit synergistic effects for the reduction of scar formation during physiological wound healing including enhanced skin cell activities, down-regulation of scar-related gene expression at later stages, accelerated wound closure after 3 weeks in a rat skin flap model, and enhanced formation of the epidermal layer along with facilitated angiogenesis. Therefore, we conclude that exogenous dual GF delivery via the Coa platform effectively augments both the quantity and quality of regenerated skin tissues without scar formation. |
