| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The investigation of the effects of micropatterns and cell-adhesive peptide on myoblast function using cell-interactive hydrogels |
| 초록 |
It is well known that chemical and structural characteristics of underlying substrate can regulate cell adhesion and growth for tissue regeneration. However, there has been no report on whether the influences of these factors are synergistic or independent to each other. Given that, we prepared peptide-incorporated hydrogels of (1) various peptide density (0.19 ± 0.04 to 0.89 ± 0.08 nmol/cm2) and (2) micro-scaled grooves with various widths (10, 25, 80 μm). We observed the C2C12 skeletal myoblasts and human smooth muscle cells cultured on the hydrogels were sensitive to peptide concentration or surface geometry, which regulate cellular adhesive morphology, proliferation, and distinct distribution of focal adhesion proteins. Our newly developed cell-adhesive peptide-incorporated hydrogels with defined patterns may be effective in investigation of the effect of these factors on cellular responses and elucidation of regulatory mechanisms underlying cell-ECM communication. |
| 저자 |
전인동1, 김석주1, 최은표2, 박정열2, 박경민3, 박기동3, 신흥수1
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| 소속 |
1한양대, 2서강대, 3아주대 |
| 키워드 |
smooth muscle; skeletal muscle; RGD; micropattern; hydrogels
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| E-Mail |
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