| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
(생물공학) 4차 산업혁명을 선도하는 생물공학 신기술 |
| 제목 |
Molecular machinery based on nucleic acid biomaterials |
| 초록 |
Nucleic acids fold into a unique 3D structure, creating a variety of functions. Importantly, these synthetic constructs can be programmed to perform a wide range of molecular functions in a controlled manner. My work has focused on generating nucleic acid-based multi-functional biopolymers and their applications. Specifically, I will first introduce an innovative selection strategy to discover functional DNA nanostructures that undergo binding-induced structure-switching (nanomechanical motion). I will subsequently show that the nanostructures can play a role of synthetic allosteric regulators that perform useful molecular functions for diagnostic and therapeutic applications. Furthermore, I will demonstrate a unique catalytic RNAs that recognize and polymerize the targeted short RNAs. Finally, I will describe a novel synthetic method to create hybrid materials capable of performing multi-step processes by integrating aptamers with engineered polymers for targeted drug delivery. |
| 저자 |
오승수 |
| 소속 |
POSTECH |
| 키워드 |
in vitro selection; aptamer; ribozyme; drug delivery; biosensor
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| E-Mail |
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