| 학회 | 한국화학공학회 |
| 학술대회 | 2010년 봄 (04/22 ~ 04/23, 대구 EXCO) |
| 권호 | 16권 1호, p.422 |
| 발표분야 | 생물화공 |
| 제목 | Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis |
| 초록 | We have previously developed an 100% genetically defined Escherichia coli strain which is able to produce 7.55 g/L L-valine with 20 g/L glucose, resulting in an impressively high yield of 0.378 g L-valine per g glucose. In this study, the development of a fed-batch fermentation process based on in silico flux response analysis was carried out. The results obtained here clearly demonstrate that the trade-off between L-valine and biomass formation should be optimized specifically towards L-valine production. [This work was supported by the Korean Systems Biology Research Project (20090065571) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further supports by the World Class University Program (R32-2008-000-10142-0) of the MEST, LG Chem Chair Professorship, IBM SUR program, and Microsoft are appreciated.] |
| 저자 | 이태우, 박진환, 김태용, 이상엽 |
| 소속 | KAIST |
| 키워드 | L-valine; in-silico; flux analysis |
| 원문파일 | 초록 보기 |
