| 학회 |
한국공업화학회 |
| 학술대회 |
2012년 봄 (05/09 ~ 05/11, 김대중컨벤션센터) |
| 권호 |
16권 1호 |
| 발표분야 |
지경부 성과발표 |
| 제목 |
Enhanced Production of Succinic Acid through Strain Improvement and Fed-batch Operations in Bioreactor Fermentations of Actinobacillus succinogenes |
| 초록 |
Succinic acid used in chemical and pharmaceutical industries is a major fermentation product biosynthesized by Actinobacillus succinogenes microbial cells. Strain improvement was performed through intensive and rational screening strategies. Biosynthetic capability of succinic acid was significantly enhanced when CO2 gas was optimally supplied into fermentor system. Therefore, to determine optimum range of CO2 mass transfer rate (kLa), kLa values were measured based on material balance of dissolved CO2 under various fermentation conditions. Impressive fed-batch fermentation results (1.5 fold higher productivity of succinic acid compared to the parallel batch process) will be also presented. |
| 저자 |
전계택1, 박상민1, 엄규리1, 이도훈2, 김상용2
|
| 소속 |
1강원대, 2한국생산기술(연) |
| 키워드 |
Succinic acid; Bioprocess engineering; Fermentation
|
| E-Mail |
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