| 초록 |
In this study, we prepared superparamagnetic iron oxide nanoparticles (IONs) capping oleic acid by thermal decomposition method. The synthesized iron oxide nanoparticles were coated with the grafted polymers which are biocompatible, and hydrophilic. The backbone of polymer is polysuccinime (PSI), a polymer biocompatible, biodegradable. Multifunctional polymers were grafted on PSI, including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) for amphiphilic structure, and biotin to interacts with receptors on cancer cell surfaces. The coated IONs were applied for magnetic hyperthermia. The structure of the polymers was confirmed by 1H NMR and FTIR. The size and distribution size of nanoparticles were defined by Transmission electron microscopy (TEM) and Dynamic light scattering (DLS). Magnetism property of IONs was measured by Superconducting quantum interference device (SQUID). The heating efficiency of the nanoparticles was estimate by hyperthermia calorimetric experiment. |
