| 초록 |
Hyaluronic acid (HA) has been used in hydrogel fabrication for biomedical applications. In general, HA-based hydrogel rapidly degrades in physiological condition. Therefore, various techniques have been tried to retard the degradation rate. In this study, silk fibroin (SF) was incorporated in HA hydrogel network via both chemical and physical crosslinking. HA and SF were modified with methacrylic group for photo-crosslinking. Both metharcylated HA and SF solutions were blended at various volume ratios. For chemical crosslinking, the blended solution was photopolymerized with a photoinitiator under UV light irradiation. Then, the hydrogel was treated with ethanol for physical crosslinking of SF chains. Before the treatment, shear elastic modulus slightly increased with an increase of SF content in hydrogel. While, the hydrogel modulus was significantly elevated after the treatment. The result of FTIR analysis indicated the property change was due to beta-transition of SF chains. |
