| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The effect of HPC in porous membrane on drug release from multi-coated bead |
| 초록 | Among the various novel drug delivery systems available in pharmaceutical industry. Oral delivery systems hold the major part because of their obvious advantages of ease administration and better patient compliance.1 So we purposed to prepare new device of granules contained water-insolubility drug for oral administration and improvement of release pattern, we prepared osmotic multi-coated granules by fluidized-bed spray coating method, and model-drug used nifedipine(ND).2 To improve release profile of nifedipine (ND) beads, water absorption force, bead size and membrane porosity are very important. The obtained beads were coated with the membrane containing different amount of HPC to form channels in membrane.3 Membrane porosity could be controlled by water soluble excipients such as HPC (hydroxypropylcellulose) to improve drug release. Drug release increased as amount of HPC increased. Because the more amount of HPC, the more channel to release drug. Fig. 1. The release profile of beads coated with different membrane Acknowledgement : This work was supported by KMOCIE (10016482). Reference 1. R.K. Verma, B. Mishra and S. Garg, Osmotically controlled oral drug delivery, Drug Dev. Ind. Pharm. 26, 695, (2000) 2. L. Liu, G. Khang, J.M. Rhee and H.B. Lee, Monolithic osmotic tablet system for nifedipine delivery, J. Control. Release 67, 309, (2000) 3. S.C. Jeong, S.K. Cheon, Y.H. Cho, M.S. Kim, B. Lee, G.Khang and H.B. Lee, The Effect of Bead Size and Drug Solubility on Drug Release from Osmotic Granule Delivery System for Nifedipine, Polymer (Korea), 29(3), 288, (2005) |
| 저자 | 정성찬1, 조영호2, 이봉1, 김문석3, 강길선2, 이해방3 |
| 소속 | 1부경대, 2전북대, 3한국화학(연) |
| 키워드 | osmotic granule; DDS; porous membrane |
