| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | The Effect of Thrombin-Immobilized Poly(Lactic-co-Glycolic Acid) as Hemostatic Agent for Treatment of Organ Laceration |
| 초록 | In this study, we designed poly(lactic-co-glycolic acid) (PLGA) meshes immobilized with thrombin which can enhance the hemostatic effect. After argon plasma treatment of PLGA, various concentration of thrombin (1, 2 and 4 IU/cm2) was conjugated to the substrate through ketimine reaction (THR-PLGA), and their efficacies on hemostasis were evaluated in vitro and in vivo. The in vitro and in vivo tests exhibited that THR-PLGA meshes exhibited higher thrombin and FXIIIa activities than pristine PLGA. In particular, THR4-PLGA showed a rapid hemostatic effect. Our findings suggested that THR4-PLGA mesh may have a potential as hemostatic agent for treatment of organ laceration. Acknowledgment: This work was supported by the Ministry of Trade, Industry & Energy (MOTIE, Korea) (10047811, 20003560 and 20004627) and by the National Research Foundation of Korea (NRF) (2017R1D1A1B03033195) of Korea. |
| 저자 | 양대혁1, 박영환2, 전흥재1 |
| 소속 | 1가톨릭대, 2한국산업기술대 |
| 키워드 | thrombin; PLGA; hemostatic agent |
