| 초록 |
In this study, we investigated the antibacterial mode of action of low molecular weight water-soluble chitosan using a combination of approaches, including antibacterial assays, culture in media with different pH values, bactericidal kinetics, cellular leakage measurements, depolarization, and electron microscopy, as well as an in vivo study utilizing a wound infection and wound healing model. The antibacterial activity of LMWSC was inversely related to pH, with higher activities being observed at lower pH values. Finally, an in vivo study utilizing a wound infection or healing model revealed that LMWSC had the potential for use as a lead compound for the development of a novel anti-infective or healing compound. |
