| 초록 |
Polymeric hydrogels releasing metal ions have been widely used for in situ tissue regeneration. Recently, it is demonstrated that zinc ion (Zn2+) exhibits excellent antibacterial activity, proliferation ability, angiogenesis, and hair follicle regeneration. Herein, we report zinc peroxide (ZnO2)-mediated in situ curable hydrogels for enhanced wound healing and in situ tissue regeneration. We fabricate hydrogels by simply mixing the functionalized polymers and ZnO2 solutions. We characterize tunable physicochemical properties, including gelation time (340-580 s), mechanical properties (2100-2600 Pa), and degradation ratio (within 3 days). Also, we demonstrate that the hydrogels release Zn2+ up to 1.27 mM and maintain until 14 days. Interestingly, our hydrogels facilitate cell proliferation, vascular recruitment, hair follicle regeneration, and collagen deposition in vivo. In sum, we suggest that our Zn2+-releasing curable hydrogels hold great potentials for tissue regeneration. |
