| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Gd2O3 Nanoparticles Coated with a Fluorescent Carbon Layer for Potential T1-Weighted Magnetic Resonance and Cells Imaging |
| 초록 |
Herein, we report the bifunctional core-shell nanoprobes that can be used as a T1-weighted magnetic resonance imaging (MRI) contrast agent and fluorescent marker for cells imaging. Gd2O3 nanoprobes coated with fluorescent carbon layer were prepared and their physicochemical properties were characterized by FETEM and XRD. A Small-animal MRI scanner (1.5 T) was utilized to measure the T1-weighted relaxivity rate (r1 = 5.57 ± 0.33 mM-1 s-1) of prepared nanoprobes. We showed that prepared nanoprobes exhibited powerful green fluorescence when they penetrated into the living cells. A pilot cytotoxicity study on L-929 fibroblastic cells showed that prepared nanoprobes are relatively safe at concentrations ≤ 8 µg/ml. Thus, prepared samples can be utilized as a promising bifunctional nanoprobe for in-vivo small animal MRI imaging and in-vitro tissues/cells study. |
| 저자 |
강문성1, 송수진1, 이유빈1, 이석현1, 박원정1, I. Selestin Raja1, Timur Sh. Atabaev2, 한동욱1
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| 소속 |
1부산대, 2Nazarbayev Univ. |
| 키워드 |
Gd2O3; MRI contrast agent; cell imaging
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| E-Mail |
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