| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
우수외국인연구자세션 |
| 제목 |
Upconversion Nanoparticles as a Contrast Agent for In Vivo Photoacoustic Imaging |
| 초록 |
Lanthanide doped upconversion nanomaterials have proven their great potentiality in modern biological applications, however, tracing UC materials from tissue depths still remains challenging due to visible emission, increased optical extinction in biological tissues and luminescence quenching in aqueous/biological conditions, which further limits their optical resolution in vivo. In this work, we report the use of NaYF4:Yb3+,Er3+ UC materials for in vivo photoacoustic imaging (PAI) by making use of hitherto unexplored luminescence quenching effect of UC materials in water. We observed a significant luminescence quenching effect of UC-α-CD in water upon 980 nm excitation. The observed non-radiative relaxation enhances thermal conductivity and subsequent PA signal of UC-α-CD in water. PAI properties of UC-α-CD were then investigated, and its application for in vivo high resolution PAI at 980 nm was demonstrated in live mice and thus proved as an excellent candidate for in vivo PAI. |
| 저자 |
Swarup Kumar Maji1, Sivaramapanicker Sreejith2, James Joseph2, Manjing Lin3, Tingchao He2, Yan Tong4, Handong Sun2, Sidney Wing-Kwong Yu5, Yanli Zhao2, 김동하1
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| 소속 |
1이화여자대, 2Nanyang Technological Univ., 3Singapore Health Services Pte. Ltd., 4National Univ. of Singapore, 5Singapore General Hospital |
| 키워드 |
upconversion nanomaterials; photoacoustic imaging
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| E-Mail |
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