| 초록 |
Recently, protein delivery systems have been extensively investigated to induce neovascularization for treatment of myocardial infarction and limb ischemia. One of the key proteins for neovascularization is the vascular endothelial growth factor (VEGF) which promotes migration, proliferation and differentiation of endothelial cells. However, intra-arterial injection or direct administration into ischemic tissues has been extremely limited due to its short lifetime in the body. We hypothesized that the controlled delivery of VEGF using a combination of alginate gels and PLGA microspheres could be achieved for a prolonged time period in vitro as well as in vivo. We tested the bioactivity of VEGF released from the delivery system, and confirmed improved new blood vessel formation in mouse model. |
