| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Therapeutic effect of budesonide-loaded porous polymer particles in a murine asthma model |
| 초록 |
Asthma is a chronic lung disease that causes inflammation and narrows the airways. Current treatment methods for asthma include prevention medications such as budesonide that is a glucocorticoid steroid. However, a long-term use as well as frequent dosages of steroids can generate many side effects to patients. For this reason, we hypothesized that budesonide-loaded porous polymer particles could be useful for the treatment of asthma, which may reduce the dosage of steroids and deposition loss. Budesonide-loaded porous PLGA particles were prepared by a double emulsion method using ammonium bicarbonate as a porogen. Various characteristics of porous particles were evaluated including the morphology, size, in vitro drug-release properties, and in vivo lung-uptake efficiency. Therapeutic effect of budesonide-loaded PLGA particles was also tested in a murine asthma model. |
| 저자 |
오유진, 이장욱, 서지영, 이근용, 윤호주, 김상헌
|
| 소속 |
한양대 |
| 키워드 |
porous PLGA particles; budesonide; asthma
|
| E-Mail |
|
