| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
대학원생 구두발표 (발표10분) |
| 제목 |
Self-assembled Polymer Nanoparticles Immobilized on Titanium Surface for Sustained Release of Simvastatin |
| 초록 |
Surface engineering with bioactive agents has been widely utilized to promote the performance of medical devices. A recent trend has focused on the development of surface-releasing systems that aim to accelerate the osseointegration of dental implants. In particular, the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. In this study, we develop a nanoparticle-immobilized titanium surface that can release simvastatin in a controlled manner. The simvastatin-loaded nanoparticles were prepared by self-assembly of 5-cholanic acid-conjugated glycol chitosan in the presence of simvastatin. The successful immobilization of nanoparticles onto titanium surfaces was confirmed by FE-SEM and XPS. The release of simvastatin lasted for up to 20 days. We suggest that simvastatin-loaded nanoparticles immobilized onto titanium may provide various medical devices with improved bone-regenerative activity. |
| 저자 |
제갈준호, 이상천, 이홍재, 최기현
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| 소속 |
경희대 |
| 키워드 |
self-assembly; nanoparticle; titanium; release; simvastatin
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| E-Mail |
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