| 초록 |
In biomaterials research, cellular interactions between cell and polymer is one of the most critical factor in the design of matrix, and the cellular adhesion peptides present in polymer hydrogels play a role in controlling multiple aspects of cell phenotype, including morphology, proliferation, and differentiation. In this study, we hypothesized that the controlling the spacer arm length of adhesion peptides could regulate the D1 stem cell phenotype. The growth rate of D1 stem cells was enhanced by increasing of the spacer arm length of RGD peptides. The increased spacer arm length of RGD peptides also promoted osteogenic and adipogenic differentiation of D1 stem cells, except condrogenic differentiation. This approach to controlling spacer arm length of adhesion peptides coupled to polymer matrices could find useful applications in tissue engineering. |
