| 초록 |
Benzylphthalazinone derivatives has been synthesized and analyzed by FT-IR spectrophotometer and 1H-NMR. Starting with phthalic anhydride two different syntheses of benzylphthalazinone derivatives are described. Benzylphthalazinone, 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one, has been commonly used as anhydrous hydrochloride salt, but it was found to form also hydrates or solvates upon recrystallization. The anhydrous form can be isolated also by precipitation from CH3CN solution or quantitatively generated from the hydrated form by heating it near 180℃. |
