| 초록 |
Tendon is a tough band of fibrous connective tissue that usually connects muscle to bone and transmit tensile loads from muscle to bone. The tendon-to-bone interfacial zone shows gradient structural change (parallel collagen fibers at the end of tendon, unmineralized fibrocartilage, mineralized fibrocartilage, and cortical bone), resulting in increased stiffness and decreased stress concentration. The tear of tendon is most commonly happened at the tendon-to-bone zone, however, the insufficient repair of the junctional zone still remained as a significant challenge in clinical area. In this study, we developed a porous polycaprolactone/Pluronic F127 membrane with reverse gradient of growth factor concentrations. As an initial attempt, its tendon-to-bone repair potential was investigated by in vitro stem cell differentiation profile along the membrane with reverse gradient of growth factor concentrations. |
