| 초록 |
Conjugated polymer dots (CPdots) have been regarded as promising nanomaterials in biomedical fields over the past decade. Thanks to unique photoelectric features, such as strong light absorbance, photo-bleaching resistance, tunable spectra property, and favorable functionality, CPdots attract increasing attenuation. In the biomedical field, conjugated polymers are mainly used for photodynamic (PDT) or photothermal therapy (PTT). CPdots as photosensitizers are utilized in PDT, which can be absorbed by light and transform oxygen molecules into reactive oxygen species to induce oxidative stress and damage cancer cells. Here, to construct a nanoagent for the synergistic effect of both treatments, PTT and PDT agents were elaborately fused into a nanotemplate. We employed photothermal Prussian blue and CPdots to synthesize the nanogent that creates PTT and PDT synergy effect under green laser irradiation, as well as the nanoagent had PDT and PTT efficacy and cancer cell imaging. |
