| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
콜로이드.계면화학_포스터 |
| 제목 |
Tuning the mechanical properties of a functional alginate microgel for stem cell-instructed delivery |
| 초록 |
The cell-instructed delivery system was designed to control the release behavior, according to the cell traction force by tuning the mechanical properties of the cell delivery carrier. First, alginate molecules were substituted with methacrylates and mixed with pure alginate to prepare microgel crosslinked with Ca2+ ions. Then, the interpenetrating covalent cross-links were incorporated in an ionically cross-linked gel. Controlling the amount of chemical cross-links tuned the microgel with varying of stiffness and toughness. Finally, the stem cells were introduced in the microgel functionalized with sulfates molecules for recapitulating the heparin structure. The stem cells differentiated were hatching and released in the functional alginate microgel with the designated work to fracture and elastic modulus. Overall, this results will be useful in designing cell-instructed delivery by systematically controlling the mechanical properties of the gel and the activity of growth factors. |
| 저자 |
오승주, 김예빈, 정나슬, 임준우, 한사라, 정재현
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| 소속 |
숭실대 |
| 키워드 |
Cell-instructed delivery; alginate micro-gel; mechanical property; heparin structure
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| E-Mail |
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