| 초록 |
For relatively insoluble drugs, nanoparticle engineering of drug crystals is an important tool for efficient and intelligent drug delivery. Recently, it was reported that polymer adsorption was a critical process to prepare nanocrystals via wet comminution process of drug particles. In this study, the nature of interactions between polymers and drugs was systematically investigated by using polymers and drugs of various different properties. The surface energy of drugs and polymers measured by contact angle measurement was found to be a factor determining the adsorption ability of polymers and the subsequent steady state particle size of drug nanocrystals. Specific interactions between functional groups appeared to play a certain role too. The higher the molecular weight of polymer, the longer time to reach the steady state of nanosuspensions resulted. The preparation of polymer-adsorbed drug nanocrystals significant relied on the physical properties of polymer used. |
