| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Double layered microsphere : encapsulation of water-soluble protein with PLGA |
| 초록 |
Poly(lactide-co-glycolide) (PLGA)-based microspheres are biodegradable particulate delivery systems providing both the protection of the drug, encapsulated inside a polymeric matrix, and its release at slow and continuous rate. In this study, BSA/PLGA double-layered microspheres(DLM) were fabricated using O/W solvent evaporation method. First, MC containing PLGA was dropped into aqueous BSA solution with surfactant. The solution was stirred several hours at room temperature. The fabricated DLM were collected by centrifugation and washed with water more than five times. After washing, the DLM were freeze for 7days. The DLM had spherical shape ,smooth surface and transparency. In fluorescent observation, we observed the fluorescent core in the DLM composed of FITC-BSA and PLGA using CFLM. Acknowledgement : This research was supported by Establishment of Nanoscopia Center of Excellence (KMOST) |
| 저자 |
고종태1, 이재호2, 육순홍3, 신형식1, 이종문1, 김문석4, 이해방5, 강길선1
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| 소속 |
1전북대, 2한화석유화학 중앙(연), 3한남대, 4한국화학(연), 5한국화학 |
| 키워드 |
PLGA; double layered microsphere; O/W solvent evaporation method
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| E-Mail |
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