| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Release Behavior of Ibuprofen Solid Dispersion with HPMC by Using Spray-drying Method |
| 초록 |
In this study, we prepared solid dispersion containing polymer by using spray-drying method. This solid dispersions formulated to improvement of dissolution property using HPMC as a water soluble. Scanning electron microscope were used to analyze surface of solid dispersion sample. DSC and XRD was used to analyze the crystallinity of solid dispersions. Fourier-transform infrared spectroscopy (FT-IR) were used to analyze the change of chemical structure characteristic of solid dispersion. DSC and XRD shows that drug crystallinity was changed. FT-IR shows that solid dispersion chemical structure comparing drug chemical structure was changed. The in vitro release behavior of solid dispersion presented at simulated gastricjuice (pH 1.2). The dissolution rate of ibuprofen was dramatically higher than pure drug and release rate of ibuprofen was decreased, as increasing polymer content rate. This research was supported by WCU (R31-20029). |
| 저자 |
오명준, 심정보, 임동균, 유석철, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Solid dispersion; Ibuprofe; Iimprovement of dissolution; HPMC
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| E-Mail |
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