| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Dual Sensitive Nanoparticles for Targeted Delivery of Anti-cancer Therapeutics |
| 초록 |
The adverse effects of the conventional cancer chemotherapy have motivated research for efficient cancer-targeting anti-cancer drugs delivery. Here, reactive oxygen species (ROS)-sensitive degradable polythioketal micelles encapsulating both anti-cancer drug and photosensitizer were delivered to HeLa cervical cancer cells via folate receptor mediated endocytosis. Poly(1,4-phyenyleneacetone dimethyl thioketal)-b-PEG amphiphilic block copolymer formed the main component of the micelles. Upon visible light treatment, the photosensitizer-generated ROS degraded the micelles to release the drug and significantly reduced HeLa cells viability in vitro. In vivo studies also presented the effectiveness of the therapeutic nanoparticles in tumour growth suppression at low anti-cancer drug dosage. This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2013R1A1A1009626). |
| 저자 |
남윤성1, 김지선2, Geok Leng Seah2
|
| 소속 |
1KAIST 신소재공학과 / KAIST Institute for NanoCentury (KINC CNiT), 2KAIST 신소재공학과 |
| 키워드 |
Polythioketal; reactive species oxygen; controlled delivery; light; anti-cancer; block copolymer
|
| E-Mail |
|
