| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.192 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The Improvement of the Storage Stability and the Gastroresistance of Lansoprazole by Sodium Alginate Coating |
| 초록 | Sodium alginate has been used in oral and topical formulations and becomes viscous liquid when dissolves in distilled water. It forms gel rapidly when it contacts with metal ion such as Ca2+, Sr2+, or Ba2+ and shrinks in low pH and re-swells in phosphate buffer solution above pH 7.0. Based on these properties, it is expected to improve the gastoresistance and storage stability of lansoprazole by blocking the acidic environment of enteric polymer when coated with sodium alginate. In this study, we evaluated the effect of sodium alginate film on the storage stability, gastroresistance and dissolution rate of enteric-coated lansoprazole. Coated with sodium alginate, lansoprazole granules showed improved storage stability and gastroresistance not much influencing dissolution rate. Acknowledgement: This work was supported by KMOHW (Grant No. HMP-98-G-2-050-A) |
| 저자 | 김정훈1, 오정민2, 강길선3, 이종문, 정제교*, 이정식*, 정상영**, 이해방** |
| 소속 | 1전북대, 2*삼천당제약 중앙(연), 3**한국화학(연) |
| 키워드 | 알긴산 나트륨; 란소프라졸; 저장안정성; 위산저항성; 용출거동 |
